DNA Damage and Mutation

DNA damage occurred by endogenous and exogenous factors, analyzes the possible talk over of every type of damage and discusses the need for different types of DNA repair. When DNA repair machinery is not working effectively, the generation of DNA lesions and mutations leads to carcinogenic transformation.  A low DNA repair potential was assign to raise cancer risk and the genes staying behind it are known as “low penetration genes.” The mutations in a cancer cell genome may encompass several distinct classes of DNA sequence change. Mutations in a cancer cell genome have been acquired during the segment of the cell lineage in which predecessors of the cancer cell already show phenotypic evidence of neoplastic change.

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